ASTLES, PETER CHARLES,GUIDETTI, ROSSELLA,TIDWELL, MICHAEL WADE,HOLLINSHEAD, SEAN PATRICK
申请号：
PE0012192011
公开号：
PE09992011A1
申请日:
2009.12.09
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
Referring to a purine Derivative of formula (i), wherein R1 is H, F, CL, c1-c2, among others R2 is tetrahidrofuranilo, tetrahidropiranilo, among others R3 is H or in combination with R4 form a pirrolin - 2 - One merged R4 is c1-c2, fluoroalquilo C1 - C2, ciclopropilo COCH3 R5 is h, or CH3 or Cf3 n is 0 OR 1 x1 and X3 are n, CH or Cr6 x2 is CH or Cr6 R6 F, CL, OCH3 or CF3, ocf3.Preferred compounds are: 8 - (2 - chlorine - pyridin-3-yl) - 6 - (2 - methyl - 4 - methyl - piperazin-1-yl) - 9 - (R) - tetrahydro - furan - 3 - il - 9h purine, 2-methyl-6 - (4 - methyl - piperazin-1-yl) - 9 - (tertahidro Piran - 4-yl) - 2 - (2 - trifluoromethyl phenyl) - 9h purine, 6 - (2 - methyl - 4 - methyl - piperazin-1-yl) - 9 - (R) - tertahidro - furan - 3 - il - 8 - (2 - triflu Orometil - phenyl) - 9h purine, among others. It is also a Pharmaceutical composition.These compounds are cannabinoid CB2 agonists of the receiver and are useful in the treatment of PainREFERIDA A UN DERIVADO DE PURINA DE FORMULA (I), DONDE R1 ES H, F, Cl, ALQUILO C1-C2, ENTRE OTROS R2 ES TETRAHIDROFURANILO, TETRAHIDROPIRANILO, ENTRE OTROS R3 ES H O EN COMBINACION CON R4 FORMA UNA PIRROLIN-2-ONA FUSIONADA R4 ES ALQUILO C1-C2, FLUOROALQUILO C1-C2, CICLOPROPILO O COCH3 R5 ES H, CH3 O CF3 n ES 0 O 1 X1 Y X3 SON N, CH O CR6 X2 ES CH O CR6 R6 ES F, Cl, CF3, OCH3 U OCF3. SON COMPUESTOS PREFERIDOS: 8-(2-CLORO-PIRIDIN-3-IL)-2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(R)-TETRAHIDRO-FURAN-3-IL-9H-PURINA, 2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(TERTAHIDRO-PIRAN-4-IL)-8-(2-TRIFLUOROMETIL-FENIL)-9H-PURINA, 2-METIL-6-(4-METIL-PIPERAZIN-1-IL)-9-(R)-TERTAHIDRO-FURAN-3-IL-8-(2-TRIFLUOROMETIL-FENIL)-9H-PURINA, ENTRE OTROS. TAMBIEN ESTA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DEL RECPETOR CANABINOIDE CB2 Y SON UTILES EN EL TRATAMIENTO DEL DOLOR
