GENZYME CORPORATION;RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
发明人:
TEICHER, BEVERLY,SCHMID, STEVEN,LAVOIE, EDMOND J.
申请号：
PE2011001416
公开号：
PE20120112A1
申请日:
2010.01.29
申请国别(地区):
PE
年份:
2012
代理人:
摘要：
It's an abiotic formula compound,Where a and B are n or CH； W is n or CH； R3 and R4 are h, C1-C6 or R3 and R4 are added together equal to or, = s, = NH or = n-r2； and Z is oh, alcoxyl C1-C6, O, O-C (= O),R1 is a C1-C6 tar replaced by one or more RZ groups； R2 is a substituted C1-C6 tar or C1-C6 tar. Dioxo-di (dioxo-dioxo-di]]]]]]] - dimethylene [dioxo (dimethylene-dimethylene-dioxo (di - (2. Dibenzo [C, H] 1, 6-naftiridina, etc.). A pharmaceutical composer was also mentioned These compounds inhibit colon cancer, kidney cancer, breast cancer, lung cancer and other carcinogens, and can be used in the treatment of colon cancer.REFERIDA A UN COMPUESTO HETEROCICLICO DE FORMULA (I), DONDE A Y B SON N O CH； W ES N O CH； R3 Y R4 SON H, ALQUILO C1-C6 O R3 Y R4 JUNTOS SON =O, =S, =NH O =N-R2； Y Y Z SON OH, ALCOXILO C1-C6, O, O-C(=O), ENTRE OTROS； R1 ES ALQUILO C1-C6 SUSTITUIDO CON UNO O MAS GRUPOS Rz； R2 ES ALQUILO C1-C6 O ALQUILO C1-C6 SUSTITUIDO. SON COMPUESTOS PREFERIDOS: 11,12-DIHIDRO-2,3-DIMETOXI-8,9-METILENDIOXI-11-[2-(DIMETILAMINO)ETIL]-5,6,11-TRIAZACRISEN-12-ONA, 2,3-DIMETOXI-8,9-METILENDIOXI-11-[(2-DIMETILAMINO)ETILO]-11H-5,6,11-TRIAZA-CRISEN-12-ONA, 8,9-DIMETOXI-2,3-METILENDIOXI-5-[2-(N,N-DIMETILAMINO)ETIL]-5H-DIBENZO[c,h]1,6-NAFTIRIDINA, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LAS TOPOISOMERASAS Y SON UTILES EN EL TRATAMIENTO DE CANCER DE COLON, CANCER RENAL, CANCER DE SENO, CANCER PULMONARH1299, ENTRE OTROS
