LEE, Chun Ho,LEE, Seung Chul,LEE, Yeon Im,EOM, Deok Ki,HAN, Mi Ryeong,KOH, Eun Ji
申请号：
PE0016322017
公开号：
PE00222018A1
申请日:
2016.04.27
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Refers to compounds derived from 1 - [1 - (phenyl sulfonyl) - 4 - 5 - methoxy phenyl 1h pyrrole - 3 - yl] - n-methylmethanamine formula (1) wherein R1, R2 and R3 are each H or Halogen R4 and R5 are each h,C1-4 alkyl, halogen, alkoxyl c1-4, haloalquilo c1-4 or haloalcoxilo C1 - 4.Preferred compounds are: 1 - (5 - (2-fluorophenyl) - 1 - (4 - methoxy - (3-chlorophenyl) sulfonyl) - 1H pyrrole - 3 - yl) - n-methylmethanamine 1 - (5 - (2-chlorophenyl) - 1 - (4 - methoxy - 3 - (4-methoxyphenyl) sulfonyl) - 1H pyrrole - 3 - yl) - n-methylMetanamina among others.These compounds possess Inhibitory activity of Proton PumpEradicator of Helicobacter pylori activity and Inhibitory activity against GPCRs (G Protein coupled receptor) to be useful in the treatment of gastritis,Helicobacter pylori and reflux esophagitisSE REFIERE A COMPUESTOS DERIVADOS DE 1-[1-(FENIL-SULFONIL)-4-METOXI-5-FENIL-1H-PIRROL-3-IL]-N-METILMETANAMINA DE FORMULA (1) DONDE R1, R2 Y R3 SON CADA UNO H O HALOGENO R4 Y R5 SON CADA UNO H, HALOGENO, ALQUILO C1-4, ALCOXILO C1-4, HALOALQUILO C1-4 O HALOALCOXILO C1-4. SON COMPUESTOS PREFERIDOS: 1-(5-(2-FLUOROFENIL)-4-METOXI-1-((3-CLOROFENIL)SULFONIL)-1H-PIRROL-3-IL)-N-METILMETANAMINA 1-(5-(2-CLOROFENIL)-4-METOXI-1-((3-METOXIFENIL)SULFONIL)-1H-PIRROL-3-IL)-N-METILMETANAMINA ENTRE OTROS. DICHOS COMPUESTOS POSEEN ACTIVIDAD INHIBIDORA DE LA BOMBA DE PROTONES, ACTIVIDAD ERRADICADORA DE HELICOBACTER PYLORI Y ACTIVIDAD INHIBIDORA CONTRA GPCR (RECEPTOR ACOPLADO A PROTEINAS G) SIENDO UTILES EN EL TRATAMIENTO DE GASTRITIS, ESOFAGITIS POR REFLUJO O HELICOBACTER PYLORI
