Godwin Kumi;Yulian Zhang;Giovanni Cianchetta;Kenneth Gordon Carson;Yingzhi Bi;Alan Main;Michael Alan Green;Gregory Glenn Zipp
发明人:
Yingzhi Bi,Kenneth Gordon Carson,Giovanni Cianchetta,Michael Alan Green,Godwin Kumi,Alan Main,Yulian Zhang,Gregory Glenn Zipp
申请号:
US13785355
公开号:
US08946415B2
申请日:
2013.03.05
申请国别(地区):
US
年份:
2015
代理人:
摘要:
Pyrazolo[1,5-a]pyrimidine-based compounds of the formula:are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by adaptor associated kinase 1 activity are also disclosed.