Pyrazolo[1,5-a]pyrimidine-based compounds, compositions comprising them, and methods of their use

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专利权人:

LEXICON PHARMACEUTICALS INC.

发明人:

CARSON KENNETH GORDON,CIANCHETTA GIOVANNI,BI YINGZHI,GREEN MICHAEL ALAN,KUMI GODWIN,MAIN ALAN,ZHANG YULIAN,ZIPP GLENN GREGORY

申请号：

NZ63072113

公开号：

NZ630721A

申请日:

2013.03.05

申请国别(地区):

NZ

年份:

2016

代理人:

摘要：

Pyrazolo[1,5-a]pyrimidine-based compounds of the formula are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed. As example of the compound is (S)-1-(2-(((3-(2-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)pyrrolidin-1-yl)-3,3-dimethylbutan-1-one.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/