2'-氟-2'-烷基-取代的或其它任選取代的呋喃核糖基嘧啶和嘌呤及其衍生物的製備

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专利权人:

PHARMASSET INC.

发明人:

CHUN, BYOUNG-KWON,WANG, PEIYUAN,DU, JINFA,RACHAKONDA, SUGUNA

申请号：

HK09108744.3

公开号：

HK1130670B

申请日:

2009.09.24

申请国别(地区):

HK

年份:

2012

代理人:

摘要：

The present invention provides (i) processes for preparing a 2'-deoxy-2'fluoro-2'-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2'-deoxy-2'-fluoro-2'-C-methyl-ss-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/