Suguna Rachakonda;Byoung Kwon Chun;Peiyuan Wang;Jinfa Du
发明人:
Byoung Kwon Chun,Jinfa Du,Suguna Rachakonda,Peiyuan Wang
申请号：
US15425198
公开号：
US20170253584A1
申请日:
2017.02.06
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present invention provides (i) processes for preparing a 2′-deoxy-2′-fluoro-2′-methyl-D-ribonolactone derivatives, (ii) conversion of intermediate lactones to nucleosides with potent anti-HCV activity, and their analogues, and (iii) methods to prepare the anti-HCV nucleosides containing the 2′-deoxy-2′-fluoro-2′-C-methyl-β-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.
