Preparation of Alkyl-Substituted 2-Deoxy-2-Fluoro-D-Ribofuranosyl Pyrimidines and Purines and Their Derivatives

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专利权人:

Pharmasset; Inc.

发明人:

Clark, Jeremy,Wang, Peiyuan,Wojciech, Stec,Chun, Byoung-Kwon,Shi, Junxing,Du, Jinfa

申请号：

AU2011200941

公开号：

AU2011200941C1

申请日:

2011.03.03

申请国别(地区):

AU

年份:

2012

代理人:

摘要：

#$%^&*AU2011200941C120120510.pdf#####Abstract The present invention provides (i) a process for preparing a 2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivative, (ii) conversion of the lactone to nucleosides with potent anti-HCV activity, and their analogues, and (iii) a method to prepare the anti-HVC nucleosides containing the 2-deoxy-2-fluoro-2-Cmethyl-o-D-ribofuranosyl nucleosides from a preformed, preferably naturally-occurring, nucleoside.

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