PREPARATION OF 2­FLUORO-2-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES

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专利权人:

PHARMASSET; INC.

发明人:

CHUN, BYOUNG-KWON,WANG, PEIYUAN,DU, JINFA,RACHAKONDA, SUGUNA

申请号：

CA2580457

公开号：

CA2580457C

申请日:

2005.09.13

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

The present invention provides (i) processes for preparing a2-deoxy-2-fluoro-2-methyl-D-ribonolactone derivatives, (ii) conversion ofintermediate lactones tonucleosides with potent anti-HCV activity, and their analogues, and (iii)methods toprepare the anti-HCV nucleosides containing the2-deoxy-2-fluoro-2-C-methyl-.beta.-D-ribofuranosylnucleosides from a preformed, preferably naturally-occurring,nucleoside.(see formula 49B)

来源网站：

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来源网址：

http://www.ckcest.cn/home/