Wilson Jr., David S.,Pogue, Sarah L.,Mikesell, Glen E.,Taura, Tetsuya,Korver, Wouter,Doyle, Anthony,Clarke, Adam,Pollard, Matthew,Tran, Stephen,Lin, Jack Tzu-Chiao
申请号：
AU2018200221
公开号：
AU2018200221A1
申请日:
2018.01.11
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
#$%^&*AU2018200221A120180201.pdf#####ABSTRACT The present invention provides a polypeptide construct comprising a peptide or polypeptide signalling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.
