David S. Wilson,Sarah L. Pogue,Glen E. Mikesell,Tetsuya Taura,Wouter Korver,Anthony G. Doyle,Adam Clarke,Matthew Pollard,Stephen Tran,Jack Tzu Chiao Lin
申请号：
US15194926
公开号：
US20160367695A1
申请日:
2016.06.28
申请国别(地区):
US
年份:
2016
代理人:
摘要：
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.
