Wilson Jr., David S.,Pogue, Sarah L.,Mikesell, Glen E.,Taura, Tetsuya,Korver, Wouter,Doyle, Anthony,Clarke, Adam,Pollard, Matthew,Tran, Stephen,Lin, Jack Tzu-Chiao
申请号：
AU2012327877
公开号：
AU2012327877B2
申请日:
2012.10.29
申请国别(地区):
AU
年份:
2017
代理人:
摘要：
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.
