TEVA PHARMACEUTICALS AUSTRALIA PTY LTD;DAVID S. WILSON JR.;SARAH L. POGUE;GLEN E. MIKESELL;TETSUYA TAURA;WOUTER KORVER;ANTHONY G. DOYLE;ADAM CLARKE;MATTHEW POLLARD;STEPHEN TRAN;JACK TZU-CHIAO LIN
发明人:
DAVID S. WILSON JR.,SARAH L. POGUE,GLEN E. MIKESELL,TETSUYA TAURA,WOUTER KORVER,ANTHONY G. DOYLE,ADAM CLARKE,MATTHEW POLLARD,STEPHEN TRAN,JACK TZU-CHIAO LIN,DAVID S. WILSON JR.
申请号：
IL23224714
公开号：
IL232247A
申请日:
2014.04.24
申请国别(地区):
IL
年份:
2018
代理人:
摘要：
The present invention provides a polypeptide construct comprising a peptide or polypeptide signaling ligand linked to an antibody or antigen binding portion thereof which binds to a cell surface-associated antigen, wherein the ligand comprises at least one amino acid substitution or deletion which reduces its potency on cells lacking expression of said antigen.
