Piperidine pyrazolo derivatives as NADPH oxidase inhibitors

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专利权人:

GENKYOTEX SA

发明人:

PAGE, PATRICK,LALEU, BENOIT,GAGGINI, FRANCESCA,ORCHARD, MIKE

申请号：

ES11709807

公开号：

ES2446727T3

申请日:

2011.02.17

申请国别(地区):

ES

年份:

2014

代理人:

摘要：

A pyrazolo piperidine derivative according to Formula (I): ** Formula ** Where R1 is selected from H； optionally substituted alkoxycarbonyl； optionally substituted C1-C6 alkyl； optionally substituted C2-C6 alkenyl； optionally substituted C2-C6 alkynyl； optionally substituted alkoxy； optionally substituted C1-C6 alkoxy alkyl； optionally substituted aminoalkyl； optionally substituted acyl； optionally substituted aryl； optionally substituted C1-C6 alkyl aryl； optionally substituted aryl C1-C6 alkyl； optionally substituted heteroaryl； optionally substituted C1-C6 alkyl heteroaryl； optionally substituted C1-C6 heteroaryl alkyl； optionally substituted C2-C6 alkenyl aryl； optionally substituted aryl C2-C6 alkenyl； optionally substituted C2-C6alkenyl heteroaryl； optionally substituted C2-C6 alkenyl heteroaryl； optionally substituted C3-C8-cycloalkyl； optionally substituted heterocycloalkyl； optionally substituted C1-C6 alkyl C3-C8-cycloalkyl； optionally substituted C3-C8-C1-C6 cycloalkyl alkyl； optionally substituted C1-C6 alkylheterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl； R2 is selected from H； optionally substituted C1-C6 alkyl； optionally substituted C2-C6 alkenyl； optionally substituted C2-C6 alkynyl； optionally substituted aryl； optionally substituted heteroaryl； optionally substituted C3-C8-cycloalkyl； optionally substituted heterocycloalkyl； optionally substituted C3-C8-C1-C6 cycloalkyl alkyl； optionally substituted C1-C6 heterocycloalkyl alkyl； optionally substituted C1-C6 alkyl and optionally substituted C1-C6 heteroaryl； R3 is selected from H, -S (O) -R4, -S (O) 2-R4, optionally substituted C3-C8-cycloalkyl, optionally substituted heterocycloalkyl and -CR5R6R7； R4 is selected from H； optionally substituted amino； optionally substituted C1-C6 alkyl； optionally substituted C2-C6 alkenyl.Un derivado de la piperidina pirazolo según la Fórmula (I):**Fórmula** En donde R1 es seleccionado de H； opcionalmente sustituido alcoxicarbonilo； opciona

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