Pyridine Pirazolo derivatives as NADPH oxidase inhibitors

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专利权人:

GenKyoTex SA

发明人:

Page, Patrick,Orchard, Mike,Laleu, Benoît,Gaggini, Francesca

申请号：

ES14190340

公开号：

ES2673405T3

申请日:

2009.09.22

申请国别(地区):

ES

年份:

2018

代理人:

摘要：

A pyrazolo-pyridine derivative according to formula (I): ** Formula ** in which G1 is H； G2 is selected from optionally substituted aryl optionally substituted and optionally substituted heteroaryl； G3 is selected from H； optionally substituted amino； optionally substituted aminoalkyl； optionally substituted aminocarbonyl； optionally substituted alkoxy； optionally substituted alkoxy-C1-C6 alkyl； optionally substituted carbonyl； optionally substituted C1-C6 alkyl； optionally substituted C2-C6 alkenyl； optionally substituted C2-C6 alkynyl； optionally substituted aryl； optionally substituted aryl-C1-C6 alkyl； optionally substituted heteroaryl； optionally substituted alkyl-C1-C6-heteroaryl； optionally substituted heteroaryl-C1-C6 alkyl； optionally substituted alkenyl-C2-C6-aryl； optionally substituted aryl-C2-C6-alkenyl； optionally substituted alkenyl-C2-C6-heteroaryl； optionally substituted heteroaryl-alkenyl-C2-C6； optionally substituted C3-C8 cycloalkyl； optionally substituted heterocycloalkyl； optionally substituted alkyl-C1-C6-cycloalkyl-C3-C8； optionally substituted cycloalkyl-C3-C8-C1-C6-alkyl； optionally substituted alkyl-C1-C6-heterocycloalkyl and optionally substituted heterocycloalkyl-C1-C6 alkyl； G4 is selected from -NR2-C (O) -R1 and - (CHR3) m- (CH2) n- R4, where R1 is selected from H； Not me； -NR5R6； optionally substituted alkoxy； optionally substituted alkoxy-C1-C6 alkyl； optionally substituted aryl； optionally substituted alkyl-C1-C6-aryl； optionally substituted aryl-C1-C6 alkyl； heteroaryl； optionally substituted alkyl-C1-C6-heteroaryl； optionally substituted heteroaryl-C1-C6 alkyl； optionally substituted C3-C8 cycloalkyl； optionally substituted alkyl-C1-C6-cycloalkyl-C3-C8； optionally substituted cycloalkyl-C3-C8-C1-C6-alkyl； optionally substituted heterocycloalkyl； optionally substituted alkyl-C1-C6-heterocycloalkyl； and optionally substituted heterocycloalkyl-C1-C6 alkyl； R2 is selected from H； optionally substituted alkoxy-C1-C6 alkyl； optionally s

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