Pyrazine pyridine derivatives as NADPH oxidase inhibitors

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专利权人:

GenKyoTex SA

发明人:

PAGE, Patrick,ORCHARD, Mike,LALEU, Benoît,GAGGINI, Francesca

申请号：

ES09815760

公开号：

ES2565436T3

申请日:

2009.09.22

申请国别(地区):

ES

年份:

2016

代理人:

摘要：

A pyrazine pyridine derivative according to Formula (I): ** Formula ** in G1 is selected from -C (O) -R1 and - (CH2) n-C (O) -R4； R1 is selected from H； of optionally substituted amino； optionally substituted alkoxy； optionally substituted C1-C6 alkyl alkoxy； -NR2R3； C1-C6 alkyl optionally substituted； of C2-C6 substituted alkenyl optionally； C2-C6 optionally substituted alkynyl； of optionally substituted aryl； C1-C6 alkyl aryl optionally substituted； C1-C6 alkyl optionally substituted aryl； of optionally substituted heteroaryl； C1-C6 alkyl heteroaryl optionally substituted； of optionally substituted C1-C6 alkyl heteroaryl； of optionally substituted C2-C6 alkenyl aryl； C2-C6 alkenyl optionally substituted alkenyl； of optionally substituted C2-C6 alkenyl heteroaryl； of optionally substituted C2-C6 heteroaryl； of optionally substituted C3-C8-cycloalkyl； of optionally substituted heterocycloalkyl； C1-C6 optionally substituted C3-C8-alkylcycloalkyl； C1-C6 optionally substituted C3-C8-alkylcycloalkyl； C1-C6 alkyl optionally substituted heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl； R2 and R3 independently selected from H, from C1-C6 alkyl optionally substituted； of C2-C6 alkenyl； C2-C6 optionally substituted alkynyl； of optionally substituted aryl； C1-C6 alkyl aryl optionally substituted； aryl C1-C6 alkyl optionally substituted； of optionally substituted heteroaryl； optionally substituted C1-C6 alkyl heteroaryl； of optionally substituted C1-C6 alkyl heteroaryl； of optionally substituted C2-C6 alkenyl aryl； C2-C6 alkenyl optionally substituted alkenyl； of optionally substituted C2-C6 alkenyl heteroaryl； of optionally substituted C2-C6 heteroaryl； of optionally substituted C3-C8-cycloalkyl； of optionally substituted heterocycloalkyl； C1-C6 optionally substituted C3-C8-alkylcycloalkyl； C1-C6 optionally substituted C3-C8-alkylcycloalkyl； optionally substituted C1-C6 alkyl heterocycloalkyl and optionally substituted heterocycloalkyl C1-C6 alkyl or-N

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