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PYRAZOLOPYRIDINE DERIVATIVES AS NADPH OXIDASE INHIBITORS
- 专利权人:
- ZHENKIOTEKS SA
- 发明人:
- PAZh Patrik (FR),ПАЖ Патрик (FR),OChARD Majk (GB),ОЧАРД Майк (GB),LALE Benua (FR),ЛАЛЁ Бенуа (FR),GADZhINI Francheska (CH),ГАДЖИНИ Франческа (CH),PAZH PATRIK,ПАЖ Патрик,OCHARD MAJK,ОЧАРД Майк,LALE BENUA,ЛАЛЁ Бенуа,GADZHINI FRANCHESKA,ГАДЖИНИ Франческа
- 申请号：
- RU2011116226/04
- 公开号：
- RU0002532161C2
- 申请日:
- 2009.09.22
- 申请国别(地区):
- RU
- 年份:
- 2014
- 代理人:
- 摘要：
- FIELD: chemistry.SUBSTANCE: invention relates to pyrazolopyridine derivatives of formula (I), a pharmaceutical composition based thereon, use for treating and/or preventing disorders or conditions associated with nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase), and an intermediate of formula (VIII). In general formula (I) G1 denotes H； G2 is selected from H； optionally substituted C1-C6-alkyl； optionally substituted C2-C6-alkenyl； optionally substituted C2-C6-alkynyl； optionally substituted phenyl； optionally substituted C1-C6-alkylaryl； optionally substituted phenyl-C1-C6-alkyl； optionally substituted heteroaryl； optionally substituted C1-C6-alkylheteroaryl； optionally substituted heteroaryl-C1-C6-alkyl； optionally substituted C2-C6-alkenylaryl； optionally substituted aryl-C2-C6-alkenyl； optionally substituted C2-C6-alkenylheteroaryl； optionally substituted heteroaryl-C2-C6-alkenyl； optionally substituted C3-C8-cycloalkyl； optionally substituted heterocycloalkyl； optionally substituted C1-C6-alkyl-C3-C8-cycloalkyl； optionally substituted C3-C8-cycloalkyl-C1-C6-alkyl； optionally substituted-C1-C6-alkylheterocycloalkyl and optionally substituted heterocycloalkyl-C1-C6-alkyl； G3 is selected from -(CH2)n-R1 and -(CH2)p-R5； G4 is selected from H； optionally substituted acyl； optionally substituted acylamino； optionally substituted acyl-C1-C6-alkyl； optionally substituted C1-C6-alkyl； optionally substituted C2-C6-alkenyl； optionally substituted C2-C6-alkynyl； optionally substituted aryl； optionally substituted C1-C6-alkylaryl； optionally substituted aryl-C1-C6-alkyl； optionally substituted heteroaryl； optionally substituted C1-C6-alkylheteroaryl； optionally substituted heteroaryl-C1-C6-alkyl； optionally substituted C2-C6-alkenylaryl； optionally substituted aryl-C2-C6-alkenyl； optionally substituted C2-C6-alkenylheteroaryl； optionally substituted heteroaryl-C2-C6-alkenyl； optionally substituted C3-C8-cycloalkyl； optionally substituted heterocycloalkyl；
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
