The present invention relates to the use of compositions comprising receptorligands obtainable by a process comprising fermenting a food material,comprising animal milk or vegetable proteins, with lactic acid bacteria toobtain a fermented food or feed material that comprises ligands of specificadrenoreceptors and/or serotonin receptors. The fermented food or feedmaterial is useful e.g. for reducing and/or stabilizing heart rate in amammal. It may furthermore be used for treatment and/or relief of erectiledysfunctions and for treatment and/or relief of benign prostate hypertrophy(BPH), in a mammal.