Isoxazole derivative as mutant isocitrate dehydrogenase 1 inhibitor

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专利权人:

Daiichi Sankyo Company, Limited;National Cancer Center

发明人:

Shoichi Saito,Masao Itoh,Tetsunori Fujisawa,Hironao Saito,Yohei Kiyotsuka,Hideaki Watanabe,Hironori Matsunaga,Yoshiko Kagoshima,Tetsuya Suzuki,Yoko Ogawara,Kazuo Kitabayashi

申请号：

US15516362

公开号：

US10040791B2

申请日:

2015.10.01

申请国别(地区):

US

年份:

2018

代理人:

摘要：

It has been found that a compound of the general formula (I) having an isoxazole skeleton has excellent inhibitory activity against mutant IDH1 protein and inhibits the production of 2-HG by this protein, while the compound is also capable of effectively inhibiting the growth of various tumors expressing the protein. In the formula, R1, R2, R3, Y, and Z are as defined in claim 1.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/