ISOXAZOLE DERIVATIVE AS MUTATED ISOCITRATE DEHYDROGENASE 1 INHIBITOR

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专利权人:

发明人:

SAITO SHOICHI,ITOH MASAO,FUJISAWA TETSUNORI,SAITO HIRONAO,KIYOTSUKA YOHEI,WATANABE HIDEAKI,MATSUNAGA HIRONORI,KAGOSHIMA YOSHIKO,SUZUKI TETSUYA,OGAWARA YOKO,KITABAYASHI KAZUO

申请号：

IN201717012199

公开号：

IN201717012199A

申请日:

2017.04.05

申请国别(地区):

IN

年份:

2017

代理人:

摘要：

It was discovered that a compound of general formula (I) that has an isoxazole skeleton has an excellent inhibitory activity on a mutated IDH1 protein inhibits 2 HG production by the aforesaid protein and can effectively inhibit the proliferation of various tumors expressing the aforesaid protein. In general formula (I) R R R Y and Z are each as defined in claim 1.

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中国工程科技知识中心

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