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Sulfonamide of benzothiophene Compound, Pharmaceutical composition comprising it and its use for the preparation of such composition
专利权人:
ALLERGAN; INC.
发明人:
XIAOXIA LIU,RICHARD L. BEARD,HAIQING YUAN
申请号:
ARP140104478
公开号:
AR098583A1
申请日:
2014.12.02
申请国别(地区):
AR
年份:
2016
代理人:
摘要:
1. Benzo parathion compound represented by formula (1),their individual enantiomers, diastereoisomers, individual tautomers, or a pharmaceutically acceptable salt thereof, wherein: X is N or CR; R is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,Nr.83040; R1 or COR1;R¹ is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,Nr.83040; R1 or COR1;R² is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,Nr.83040; R1 or COR1;R³ is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,Nr.83040; R1 or COR1;R⁴ is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,Nr.83040; R1 or COR1;R⁵ is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,Nr.83040; R1 or COR1;R⁶ is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,NR¹⁰OR¹¹ or COR¹²;R⁷ is hydrogen, halogen, CN, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, OR⁹,NR¹⁰OR¹¹ or COR¹²;R⁸ is substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₃₋₈ cycloalkyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl; n is 0, 1 or 2; R⁹ is hydrogen or substituted or unsubstituted C₁₋₆ alkyl; R¹⁰ is hydrogen or substituted or unsubstituted C₁₋₆ alkyl; R¹¹ is hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted heterocycle or substituted or unsubstituted C₆₋₁₀ aryl; R¹² is hydrogen, hydroxyl, substituted or unsubstituted heterocycle, substituted or unsubstituted C₆₋₁₀ aryl or substituted or unsubstituted C₁₋₆ alkyl;In addition to formula compounds (2) and (3). A pharmaceutical ingredient containin
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