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SPIRO-OXINDOLE COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS
专利权人:
发明人:
申请号:
HK12108941.9
公开号:
HK1168104A
申请日:
2012.09.12
申请国别(地区):
HK
年份:
2012
代理人:
摘要:
Claim 1.A compound of formula (1): J and K are each independently 0, 1, 2 or 3 Q - C (A1a) H - C (o) -, - O -, - S (o) M (where M is 0, 1 or 2) CF2 -, -, - C (O) o -, - C (o) n (R5) - or - N (R5) C (o) - O - OR5 A1A Hydrogen r1 is Hydrogen, alkyl, alquenilo, alquinilo haloalquilo, cycloalkyl, aryl, Cilcoalquilalquilo heteroaryl, heterociclilo,,, - C (o) - R8 R5 R8 -, - C (o) OR5 R8 -, - C (o) n (R4, R5),- (S) - 2 - (R5, R9 - s or - R5) M (where M is 0, 1 or 2), OR5 R8, R9 R8 - CN, - P (o) (OR5) 2, or - - - - OR5 R0 or R1 R9 or aralquilo is replaced with - C (o) n (r6) where: R6 R7 is Hydrogen, alkyl, aryl or aralquilo and R7 is Hydrogen, alkyl, haloalquilo - R9, - CN, - - - - OR5 R9 R9 N (R4, R5), aralquilo, cycloalkyl, aryl, C Icloalquialquilo, heterociclilo, heterociclialquilo, heteroaryl, or R6 and R7, heteroarilalquiloTogether with nitrogen which are United to form a heterociclilo or heteroaryl Group and where each aralquilo, cycloalkyl, aryl, cicloalquilalquilo, heterociclilo, heterociclilalquilo heteroaryl heteroaryl, and for R6 and R7 can be optionally substituted by one or more substituents are Selected from the group consisting of alkyl, cycloalkyl, aryl, aralquilo, Halo, haloalquilo,R8 (R8 OR5, heterociclilo and heteroaryl r1 is aralquilo or optionally substituted with one or more substituents selected from the group consisting OR5 - R8 -, - C (o) OR5, Halo, haloalquilo, alkyl, Nitro, cyano, aryl, heteroaryl or aralquilo, heterociclilo and r1 IS - R9 R11 (R10) - n, - N - R9 (R12) C (o) - R9 R11 or - N (R10) C (o) n (R10) R11: every R10 is Hydrogen, alkyl, aryl,Aralquilo or heteroaryl each haloalquilo R11 is Hydrogen, alkyl, cycloalkyl, aryl, cicloalquilalquilo, aralquilo, heterociclilo, heterociclilalquilo, heteroaryl, heteroarilalquilo - R9, OC (or R5, R9) - C (o) OR5 R9 -, - C (o) n (R4, R5, R9) - - C (o) - R5, R9 N (R4, R5, R9) - - - - OR5 R9, or CN R12 is Hydrogen, alkyd ILO, aryl, or aralquilo R5 - C (o) and where each group aralquilo, cycloalkyl, ary
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