OR, YAT SUN,MALLISTER, NICOLE V.,RHODIN, MICHAEL H. J.,LIN, KAI,PANARESE, JOSEPH,YU, JIANMING,BLAISDELL, THOMAS P.,KIM, IN JONG,SHOOK, BRIAN C.
申请号：
ARP180102807
公开号：
AR112704A1
申请日:
2018.09.28
申请国别(地区):
AR
年份:
2019
代理人:
摘要：
Claim 1: A method of treating respiratory syncytial virus infection in humans in a subject in need thereof, comprising administering to the subject a compound represented by formula [1], or a pharmaceutically acceptable salt of the themselves, where: R¹ is selected from the group comprising: 1) hydrogen； 2) halogen； 3) CN； 4) optionally substituted C₁₋₈ alkyl； and 5) optionally substituted C₁₋₈-O-R¹¹ alkyl； R² and R⁵ are each independently selected from the group comprising: 1) hydrogen； and 2) optionally substituted C₁₋₈ alkyl；A is selected from the group comprising: 1) optionally substituted C ciclo cycloalkyl； 2) optionally substituted C₃₋₁₂ cycloalkenyl； 3) optionally substituted 3-12 membered heterocycloalkyl； 4) optionally substituted aryl； and 5) optionally substituted heteroaryl； R³ is hydrogen or R¹¹；R⁴ is selected from the group comprising: 1) optionally substituted C ciclo cycloalkyl； 2) optionally substituted C₃₋₁₂ cycloalkenyl； 3) optionally substituted 3 to 12 membered heterocyclyl； 4) optionally substituted aryl； 5) optionally substituted heteroaryl； 6) optionally substituted aryl-O； 7) optionally substituted heteroaryl-O； 8) optionally substituted aryl-C₁₋₄-alkyl； and 9) optionally substituted heteroaryl-C₁₋₄-alkyl； each R⁶ is the same or different and independently selected from hydrogen, halogen, hydroxyl, protected hydroxyl, cyano, amino, protected amino, nitro, optionally substituted C₁₋₈ alkyl,(a) Alternative replacement, - nhc8321； 383222； R2,-NrºR830808，Y-CO-NrºR8308；R¹¹ and R¹² are each independently selected from the group comprising: 1) optionally substituted C₁₋₈ alkyl； 2) optionally substituted C₂₋₈ alkenyl； 3) optionally substituted C₂₋₈ alkynyl； 4) optionally substituted C₃₋₈ cycloalkyl； 5) optionally substituted C₃₋₈ cycloalkenyl； 6) optionally substituted 3-8 membered heterocycloalkyl； 7) optionally substituted aryl； and 8) optionally substituted heteroaryl； R¹³ and R¹⁴ are each independently selected from hydrogen, optionally substit
