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5,8 dihydro - 6h pyrazolo [3,4 - h] quinazolines as inhibitors of igf-1r / ir
专利权人:
BOEHRINGER INGELHEIM INTERNATIONAL GMBH
发明人:
MATTHIAS TREU
申请号:
ARP130100189
公开号:
AR089776A1
申请日:
2013.01.22
申请国别(地区):
AR
年份:
2014
代理人:
摘要:
Compounds suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation, pharmaceutical preparations containing compounds of this type and use as drugs. Claim 1: A compound of the general formula (1) characterized in that: R¹ indicates C₁₋₄ alkyl;R² indicates hydrogen or C₁₋₄-alkyl;R³ indicates hydrogen or C₁₋₄ alkyl;n indicates 0 or 1; ring A is 5-6 membered phenyl or heteroaryl; each R⁴ is independently selected from one of halogen, C₁₋₄ alkoxy,C83218331y-cn No.; P means 0, 1 or 2; ring B is 5 member heteromorphic; each r83099 is independent r7495;; 1 or a group, optionally one or more r7495;; 1 and / or r7580801; 1identical or different selected from C₁₋₆-alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;haloalkyl C₁₋₆,cycloalkyl C₃₋₆,cycloalkenyl C₄₋₆,1. Phenyl, isomer of 5-6 members and isomer of 3-7 members; each r7495;]-7580; - 7580; - 1,Halogen, - CN, - C (o) r7580;; 1-C (O) OR-C (O) NR R-S (O) R-S (O) NR R-NHC (O) Rᶜ¹ and -N (C₁₋₄-alkyl) C (O) Rᶜ¹;Each r7580801;; 1 represents hydrogen or a group independent of the other r75801, and one or more r7496;; 1 and / or r7497;; 1identical or different selected from C₁₋₆-alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;haloalkyl C₁₋₆,cycloalkyl C₃₋₆,cycloalkenyl C₄₋₆,1. Phenyl, isomer of 5-6 members and isomer of 3-7 members; each r7496;; 1 is independent of - or7497;,Nr.7497;]Halogen, - CN, - C (o) r7497;; 1-C (O) OR-C (O) NR R-S (O) R-S (O) NR R-NHC (O) R y -N (alquilo C) C (O) RR7497;]identical or different selected from C₁₋₆-alkyl,C₂₋₆ alkenyl,1. C 83228331 asphalt;haloalkyl C₁₋₆,cycloalkyl C₃₋₆,cycloalkenyl C₄₋₆,1. Phenyl, isomers of 5-6 members and isomers of 3-7 members; each r758484; 1. Selected independently without interfering with - or75011;-7501; - 750101; - 1,Halogen, - CN, - C (o) r7501;; 1,-C (O) OR-C (O) NR R-S (O) R-S (O) NR R-NHC (O) Rᵍ¹ and -N (C₁₋₄-alkyl) C (O) Rᵍ¹;each Rᵍ¹ independently of one another indicates hydrogen or C₁₋₆ alkyl;Q is 0, 1 or 2; ring C is phenyl or 5-6 non
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