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稠合雜環衍生物,含有其之醫藥組成物及其醫藥用途
专利权人:
LTD.;KISSEI PHARMACEUTICAL CO.
发明人:
NOBUHIKO FUSHIMI,伏见信彦,伏見信彥,SHIGERU YONEKUBO,米漥滋,HIDEYUKI MURANAKA,村仲秀幸,HIROAKI SHIOHARA,盐原宽明,鹽原寬明,HIROTAKA TERANISHI,寺西弘孝,KAZUO SHIMIZU,清水和夫,FUMIAKI ITO,伊东史显,伊東史顯,MASAYUKI ISAJI,伊佐治
申请号:
TW093108839
公开号:
TWI377210B
申请日:
2004.03.31
申请国别(地区):
TW
年份:
2012
代理人:
摘要:
The present invention is to provide condensed heterocyclic derivatives represented by the general formula: Wherein R1 represents hydrogen, halogen, hydroxy etc.; R2 represents hydrogen, halogen or alkyl; R3 and R4 represent hydrogen, hydroxy, halogen etc,; Q represents alkylene etc.; ring A represents aryl or heteroaryl; and G represents or or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert excellent inhibitory activities in human SGLT and are useful as drugs for the prevention or treatment of a disease associated with hyperglycemia such as diabetes, postprandial hyperglycemia, impaired glucose tolerance, diabetic complications, obesity etc., and pharmaceutical compositions comprising the same, and pharmaceutical uses thereof.本發明提供顯現優異之人體SGLT活性阻礙作用,和對起因於糖尿病、食後高血糖、耐糖能力異常、糖尿病性合併症、肥胖症等高血糖症之作為病患預防或治療藥有用之通式為;(I);(R1為H、鹵素、OH等,R2為H、鹵素、或烷基,R3及R4各為H、OH、鹵素等,Q為伸烷基等,環A為芳基或雜芳基,G為;(G1);或;(G2);)所示的稠合雜環衍生物及其在藥理學上可容許之鹽類,或其藥物前體,及含有其等之醫藥組成物,及其醫藥用途。
来源网站:
中国工程科技知识中心
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http://www.ckcest.cn/home/

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