Compounds of formula I and a method for their preparation are described:where R1, R2and R3are the same or different and signify hydrogens, halogens, alkyl, nitro, amino, alkylcarbonylamino, alkylamino or dialkylamino group R4signifies -alkyl-aryl or -alkyl-heteroaryl X signifies CH2, oxygen atom or sulphur atom n is 2 or 3 including the individual (R)- and (S)-enantiomers or mixtures of enantiomers thereof and including pharmaceutically acceptable salts and esters thereof.The compounds have potentially valuable pharmaceutical properties for the treatment of cardiovascular disorders such as hypertension and chronic heart failure.本發明係描述一種式I化合物及其製備方法:其中R1、R2及R3可為相同或不同且表示氫、鹵素、烷基、硝基、胺基、烷羰基胺基、烷胺基或二烷胺基;R4表示-烷基-芳基或-烷基-雜芳基;X表示CH2、氧原子或硫原子;n為2或3;包含個別之(R)-及(S)-對映異構物或其對映異構物的混合物;及包含其醫藥上可接受的鹽及酯。該等化合物具有治療心血管疾病(例如高血壓及慢性心臟衰竭)之潛在有價值的醫藥性質。(無元件符號說明)
