COMPUESTOS ETERES ARALQUIL BENCILICOS, PROCESO DE PREPARACION DE LOS MISMOS, COMPUESTOS INTERMEDIARIOS, USO DE DICHOS COMPUESTOS, METODO DE TRATAMIENTO Y/O PREVENCION, COMPOSICION FARMACEUTICA Y MEDICAMENTO QUE CONTIENE DICHOS COMPUESTOS.
ARTUR FRANZ KEPPLER,SERGIO LUIZ SACURAI,MARCIO HENRIQUE ZAIM,CARLOS EDUARDO DA COSTA TOUZARIM
申请号：
MX2012002276
公开号：
MX2012002276A
申请日:
2010.08.27
申请国别(地区):
MX
年份:
2012
代理人:
摘要：
The present invention describes new anti-fungal, benzyl aralkyl ether compounds of formula (I), where: Ar stands for aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl； R1, R2, R4 and R5 independently stand for hydrogen, halogen, C1-6 alkyl； R3 stands for halogen, C1-6 alkyl or O-R', where R' stands for hydrogen or lower alkyls； R6 stands for aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R', where R' stands for hydrogen or lower alkyls, the aryl substituents being a halogen or a tetrazolyl radical； n and m independently equal an integer from 0 to 5, provided that, when Ar stands for imidazolyl, R3 for chlorine, R6 for p-phenyl and R1, R2, R4 and R5 for hydrogen, n is different from 2. When n and m differ from 0 and 1, R3 or R6 may represent optionally different substituents. The present invention also relates to the pharmaceutically acceptable salts, solvates, pro-drugs, esters, enantiomers and/or diastereoisomers thereof, or mixtures thereof, to the methods for preparing said compounds, to intermediate compounds, to pharmaceutical compositions comprising said compounds and/or derivatives, to medicaments comprising said compounds and/or derivatives, as well as to the uses of and methods using said compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by micro-organisms such as fungi, bacteria and/or protozoa, for inhibiting the proliferation and/or survival of said micro-organisms, for treating and/or preventing micro-organism growth on an individual, and for producing a medicament.La presente invención describe nuevos compuestos antifúngicos que son éteres aralquil bencílicos, de la fórmula (I): (ver fórmula (I)) donde: Ar representa arilo, imidazolilo, 1,2,4-triazolilo o bencimidazolilo； R1, R2, R4 y R5 representan, en forma independiente, hidrógeno, halógeno, alquilo C1-6； R3 representa halógeno, alquilo C1-6 u O-R', donde R' representa hidrógeno o alquilos inferiores； R6 representa arilo, arilo susti
