Benzyl aralkyl ether compounds, method for preparing same, intermediate compounds, use of said compounds, method for treatment and/or prevention, pharmaceutical composition and medicament containing same
Sérgio Luiz Sacurai;Carlos Eduardo da Costa Touzarim;Artur Franz Keppler;Marcio Henrique Zaim
发明人:
Artur Franz Keppler,Sérgio Luiz Sacurai,Marcio Henrique Zaim,Carlos Eduardo da Costa Touzarim
申请号：
US13389741
公开号：
US08975289B2
申请日:
2010.08.27
申请国别(地区):
US
年份:
2015
代理人:
摘要：
This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I):where Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil；R1, R2, R4 and R5 are independently hydrogen, halogen, C1-6 alkyl；R3 represents halogen, C1-6alkyl or O—R′ where R′ represents hydrogen or lower alkyl；R6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O—R′ where R′ represents hydrogen or lower alkyl； being the substituents of the aryl a halogen or a radical tetrazolyl；n and m represent independently an integer between 0 and 5；With the proviso that when Ar is imidazolil, R3 is chlorine, R6 is p-phenyl and R1, R2, R4 and R5 are hydrogen, n must be different from 2.When n and m are not 0 and 1, R3 or R6 can be represented by substituents not necessarily equal.
