Artur Franz Keppler,Carlos Eduardo da Costa Touzarim,Marcio Henrique Zaim,Sérgio Luiz Sacurai
申请号：
BRPI0904249
公开号：
BRPI0904249B1
申请日:
2009.08.28
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
aralkyl benzyl ether compounds, process for preparing them, intermediate compounds, use of said compounds, method of treatment and / or prevention, pharmaceutical composition and medicament thereof containing the present invention describes novel antifungal compounds which are aralkyl benzyl ethers of the formula ( 1): where: ar represents aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl； R 1, R 2, R 4 and R 5 independently represent hydrogen, halogen, C 1-6 alkyl； R3 represents halogen, C1-6 alkyl or o-R ', where R' represents hydrogen or lower alkyls； R 6 is aryl, substituted aryl, trifluoromethyl, trichloromethyl or o-R 'where r' represents hydrogen or lower alkyl, the aryl substituents being a halogen or a tetrazolyl radical； n and m independently represent an integer from 0 to 5； provided that when air is imidazolyl, r3 is chlorine, r6 is p-phenyl and r ~ 1, r ~ 2 ~, r ~ 4 ~ and r ~ 5 ~ are hydrogen, it should not differ from 2. when neither different from o and 1, r 3 or r 6 may be represented by substituents not necessarily the same as the present invention also refers to their pharmaceutically acceptable salts, solvates, prodrugs, esters, enantiomers and / or diastereoisomers, or mixtures thereof, processes for the preparation of said compounds, intermediate compounds, pharmaceutical compositions comprising said compounds and / or derivatives, medicaments comprising said compounds and / or derivatives, as well as the uses and methods of said compounds and / or derivatives for the treatment and / or prevention of conditions and / or diseases caused by microorganisms, such as fungi, bacteria and / or protozoa, for inhibiting the proliferation and / or survival of said microorganisms, for all treatment and / or prevention of colonization of microorganisms in an individual, and for the manufacture of acompostos éteres aralquil benzílicos, processo de preparação dos mesmos, compostos intermediários, uso dos referidos compostos, método de tratamento e/ou prevençã
