BENZYL ARALKYL ETHER COMPOUNDS, METHOD FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME
KEPPLER ARTUR FRANZ,케플러, 아르투어 프란쯔,SACURAI SERGIO LUIZ,사쿠라이, 세르지오 루이쯔,ZAIM MARCIO HENRIQUE,자임, 마르시오 헨리꼬,TOUZARIM CARLOS EDUARDO DA COSTA,투자림, 카르로스 에두아도 다 코스타
申请号：
KR1020127007355
公开号：
KR1020120050490A
申请日:
2010.08.27
申请国别(地区):
KR
年份:
2012
代理人:
摘要：
This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I): wherein: Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil； R 1 , R 2 , R 4 and R 5 are independently hydrogen, halogen, C 1-6 alkyl； R 3 represents halogen, C 1-6 alkyl or O-R' where R'represents hydrogen or lower alkyl； R 6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R' where R' represents hydrogen or lower alkyl； being the substituents of the aryl a halogen or a radical tetrazolyl； n and m represent independently an integer between 0 and 5； With the proviso that when Ar is imidazolil, R 3 is chlorine, R 6 is p -phenyl and R 1 , R 2 , R 4 and R 5 are hydrogen, n must be different from 2. When n and m are not 0 and 1, R 3 or R 6 can be represented by substituents not necessarily equal. This invention also refers to their salts, solvates, prodrugs, esters, enantiomers and/or pharmaceutically acceptable diastereoisomers, or mixtures thereof, processes for the preparation of these compounds, intermediate compounds, pharmaceutical compositions comprising such compounds and/or derivatives, including those compounds and/or derivatives, as well as the uses and methods of these compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by microorganisms such as fungi, bacteria and/or protozoa, for the inhibition of proliferation and/or survival of said microorganisms, for the treatment and/or prevention of colonization of microorganisms in an individual, and for the manufacture of a medicine."아랄킬 벤질 에터 화합물, 그의 제조방법, 중간체 화합물, 상기 화합물의 용도, 치료 및/또는 예방 방법, 상기 화합물을 포함하는 약학적 조성물 및 약"본 발명은 화학식 (I)의 아랄킬 벤질 에터인 신규한 항진균 화합물을 기술한다: 상기 식에서Ar은 아릴(aryl), 이미다졸일(imidazolyl), 1,2,4-트리아졸일(1,2,4-triazolyl), 벤즈이미다졸일(benzimidazolyl)이고；R1, R2, R4 및 R 5 은 독립적으로 수소, 할로겐, C1-6 알킬이고； R3 는 할로겐. C1-6 알킬 또는 O-R'의 치환기이고 여기에 있어서 R'은 수소 또
