BENZYL ARALKYL ETHER COMPOUNDS, METHODS FOR PREPARING SAME, INTERMEDIATE COMPOUNDS, USE OF SAID COMPOUNDS, METHOD FOR TREATMENT AND/OR PREVENTION, PHARMACEUTICAL COMPOSITION AND MEDICAMENT CONTAINING SAME
KEPPLER ARTUR FRANZ,ZAIM MARCIO HENRIQUE,SACURAI SERGIO LUIZ,TOUZARIM CARLOS EDUARDO DA COSTA
申请号：
ZA201201442
公开号：
ZA201201442B
申请日:
2012.02.27
申请国别(地区):
ZA
年份:
2012
代理人:
摘要：
This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I): wherein: Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil； R 1 , R 2 , R 4 and R 5 are independently hydrogen, halogen, C 1-6 alkyl； R 3 represents halogen, C 1-6 alkyl or O-R' where R'represents hydrogen or lower alkyl； R 6 represents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R' where R' represents hydrogen or lower alkyl； being the substituents of the aryl a halogen or a radical tetrazolyl； n and m represent independently an integer between 0 and 5； With the proviso that when Ar is imidazolil, R 3 is chlorine, R 6 is p -phenyl and R 1 , R 2 , R 4 and R 5 are hydrogen, n must be different from 2. When n and m are not 0 and 1, R 3 or R 6 can be represented by substituents not necessarily equal. This invention also refers to their salts, solvates, prodrugs, esters, enantiomers and/or pharmaceutically acceptable diastereoisomers, or mixtures thereof, processes for the preparation of these compounds, intermediate compounds, pharmaceutical compositions comprising such compounds and/or derivatives, including those compounds and/or derivatives, as well as the uses and methods of these compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by microorganisms such as fungi, bacteria and/or protozoa, for the inhibition of proliferation and/or survival of said microorganisms, for the treatment and/or prevention of colonization of microorganisms in an individual, and for the manufacture of a medicine.
