Benzyl aralkyl ether compounds, method for preparing same, intermediate compounds, use of said compounds, method for treatment and/or prevention, pharmaceutical composition and medicament containing same
Keppler, Artur Franz,Sacurai, Sergio Luiz,Zaim, Marcio Henrique,Touzarim, Carlos Eduardo Da Costa
申请号：
AU2010286266
公开号：
AU2010286266B2
申请日:
2010.08.27
申请国别(地区):
AU
年份:
2015
代理人:
摘要：
The present invention describes new anti-fungal, benzyl aralkyl ether compounds of formula (I), where: Ar stands for aryl, imidazolyl, 1,2,4-triazolyl, benzimidazolyl； R1, R2, R4 and R5 independently stand for hydrogen, halogen, C1-6 alkyl； R3 stands for halogen, C1-6 alkyl or O-R', where R' stands for hydrogen or lower alkyls； R6 stands for aryl, substituted aryl, trifluoromethyl, trichloromethyl or O-R', where R' stands for hydrogen or lower alkyls, the aryl substituents being a halogen or a tetrazolyl radical； n and m independently equal an integer from 0 to 5, provided that, when Ar stands for imidazolyl, R3 for chlorine, R6 for p-phenyl and R1, R2, R4 and R5 for hydrogen, n is different from 2. When n and m differ from 0 and 1, R3 or R6 may represent optionally different substituents. The present invention also relates to the pharmaceutically acceptable salts, solvates, pro-drugs, esters, enantiomers and/or diastereoisomers thereof, or mixtures thereof, to the methods for preparing said compounds, to intermediate compounds, to pharmaceutical compositions comprising said compounds and/or derivatives, to medicaments comprising said compounds and/or derivatives, as well as to the uses of and methods using said compounds and/or derivatives for the treatment and/or prevention of conditions and/or diseases caused by micro-organisms such as fungi, bacteria and/or protozoa, for inhibiting the proliferation and/or survival of said micro-organisms, for treating and/or preventing micro-organism growth on an individual, and for producing a medicament.
