OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOST'JU "FARMINTERPRAJSEZ";OBSHCHESTVO S OGRANICHENNOJ OTVETSTVENNOSTJU "FARMINTERPRAJSEZ"
发明人:
NEBOL'SIN Vladimir Evgen'evich (RU),НЕБОЛЬСИН Владимир Евгеньевич (RU),KROMOVA Tat'jana Aleksandrovna (RU),КРОМОВА Татьяна Александровна (RU),ZhELTUKhINA Galina Aleksandrovna (RU),ЖЕЛТУХИНА Галина Але,NEBOLSIN VLADIMIR EVGENEVICH,НЕБОЛЬСИН Владимир Евгеньевич,KROMOVA TATJANA ALEKSANDROVNA,КРОМОВА Татьяна Александровна,ZHELTUKHINA GALINA ALEKSANDROVNA,ЖЕЛТУХИНА Галина Александровна
申请号：
RU2013116826/04
公开号：
RU0002562773C2
申请日:
2013.04.12
申请国别(地区):
RU
年份:
2015
代理人:
摘要：
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to derivatives of glutarimides of general formula (I) and their pharmaceutically acceptable salts, medication and pharmaceutical composition on their basis, their application and method of treating diseases of upper respiratory ways, as well as to method of obtaining formula (I) derivatives of glutarimides. In general formula (I) m stands for integer from 0 to 2； Ra 1 and Rc 1 stand for hydrogen, C1-C6alkyl, -NH2 or hydroxygroup； Rb 1, Rd 1 and Re 1 stand for hydrogen or C1-C6alkyl； Rf 1 stands for hydrogen； R2 stands for hydrogen, C1-C6alkyl, group -C(O)OH or -C(O)OC1-C6 alkyl； R3 stands for: 5-membered saturated or unsaturated heterocyclic group, containing from 1 to 4 heteroatoms, selected from N, O and S, optionally substituted with from 1 to 3 substituents, selected from halogen, C1-C6alkyl, C1-C6alkoxy, group -C(O)OH and phenyl； 6-membered saturated or unsaturated heterocyclic group, containing 1 or 2 heteroatoms, selected from N and O, optionally substituted with halogen； 5-membered unsaturated heterocyclic group, containing 1 heteroatom, selected from N and S, optionally substituted with 1 or 2 substituents, selected from C1-C6alkyl, condensed with phenyl or 6-membered unsaturated heterocyclic group, containing nitrogen atom, optionally substituted with one substituent, selected from hydroxygroup or halogen； 6-membered unsaturated cyclic or heterocyclic group, containing 2 N atoms, condensed with 5- or 6-membered unsaturated heterocyclic group, containing from 1 to 3 heteroatoms, selected from N and S； group of formula .EFFECT: obtaining composition for treatment of upper respiratory ways diseases.25 cl, 5 tbl, 11 exИзобретение относится к производным глутаримидов общей формулы (I) и их фармацевтически приемлемым солям, лекарственному средству и фармацевтической композиции на их основе, их применению и способу лечения заболеваний верхних дыхательных путей, а также способу получения производных гл
