A method of economically producing stable and bio-available glutathione comprising immersing glutathione particles in an edible oil preferably selected from at least one of almond, coconut, grapeseed and olive reducing the average size of glutathione particles to not more than 50 microns and preferably 1 or less and adding a de-agglomeration agent comprising at least one selected from surfactants or chelating agents. A method of administering bio-available glutathione, prepared according to the foregoing, to a patient in a desired dose by a method selected from oral, pulmonary, rectal, sublingual, transdermal, and vaginal.