Simmen, Kenneth Alan,Raboisson, Pierre Jean-Marie Bernard,Tahri, Abdellah,Surleraux, Dominique Louis Nestor Ghislain,Vendeville, Sandrine Marie Helene,De Kock, Herman Augustinus,Van De Vreken, Wim,Mc
申请号：
AU2006274858
公开号：
AU2006274858B2
申请日:
2006.07.28
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
Inhibitors of HCV of formula (I), and the -oxides, salts, and stereochemicallyisomeric forms thereof, wherein R is aryl or a saturated, a partiallyunsaturated or completely unsaturated 5 or 6 membered monocyclic or 8 to 12 memberedbicyclic heterocyclic ring system containing one nitrogen, and optionallyone to three oxygen, sulfur or nitrogen, wherein said ring system may be optionallysubstituted； L is a direct bond, -O-. -O-Calkanediyl-, -O-CO-,-O-C(=O)-NR- or -O-C(=O)-NR-Calkanediyl-；R is hydrogen, -OR, -C(O)OR, -C(=O)R,-C(=O)NRR, -C(=O)NHR, -NRR,-NHR, -NHSONRR, -NRSOR,or -B(OR)； R and R are hydrogenor Calkyl； or R and R taken together may forma Ccycloalkyl ring； n is 3, 4, 5, or 6； p is 1 or 2； aryl is phenyl, naphthyl,indanyl, or 1,2,3,4-tetrahydronaphthyl, each of which may be optionally substitutedHet is a 5 or 6 membered saturated, partially unsaturated or completely unsaturatedheterocyclic ring containing 1 to 4 heteroatoms each independently selectedfrom nitrogen, oxygen and sulfur, being optionally condensed with a benzenering, and wherein the group Het as a whole may be optionally substituted ； pharmaceuticalcompositions containing compounds (I) and processes for preparing compounds(I). Bioavailable combinations of the inhibitors of HCV of formula (I) with ritonavirare also provided.
