K.U.LEUVEN RESEARCH & DEVELOPMENT;GILEAD SCIENCES, INC.;PUERSTINGER, GERHARD
发明人:
NEYTS, JOHAN,PUERSTINGER, GERHARD,DE CLERCQ, ERIK
申请号：
ES03762361
公开号：
ES2372277T3
申请日:
2003.07.03
申请国别(地区):
ES
年份:
2012
代理人:
摘要：
Use of an imidazo [4,5-c] pyridine derivative of formula (Z), or of a pharmaceutically acceptable salt thereof, for the preparation of a medicament intended for the treatment or prevention of a viral infection in which: - dotted lines represent an optional double bond, provided that neither of the two double bonds are adjacent to each other, and that the dotted lines represent at least 3, optionally 4, double bonds； - R 1 is selected from hydrogen, aryl unsubstituted or substituted with one or more R 6； heterocyclic ring unsubstituted or substituted with one or more R 6； C3-10 cycloalkyl unsubstituted or substituted with one or more R 6； and C4-10 cycloalkenyl not substituted or substituted with one or more R 6； - And it is selected from the group consisting of simple link； OR； S (O) m； NR 11； and a divalent, saturated or unsaturated, substituted or unsubstituted C1-10 hydrocarbon group that optionally includes one or more heteroatom (s) in the main chain, said heteroatom (s) being selected from the group consisting of O, S and N ； - each R 2 and R 4 is independently selected from the group consisting of hydrogen； C1-18 alkyl； C1-18 alkenyl； C1-18 alkynyl； C1-18 alkoxy； C1-18 alkylthio； halo； OH； CN； NO2； NR 7 R 8； OCF3； haloalkyl； C (= O) R 9； C (= S) R 9； SH； aryl； aryloxy； arylthio； arylalkyl； C1-18 hydroxyalkyl； C3-10 cycloalkyl； C3-10 cycloalkyloxy； C3-10 cycloalkylthio； C3-10 cycloalkenyl； C3-10 cycloalkynyl； 5 or 6 link heterocyclic, oxyheterocyclic or thioheterocyclic ring； or, when one of R 25 or R 26 is different from hydrogen, R 2 or R 4 is selected from (= O), (= S) and (= NR 27)； - X is selected from the group consisting of a divalent, saturated or unsaturated, substituted or unsubstituted C1-10 hydrocarbon group that optionally includes one or more heteroatoms in the main chain (with the proviso that the heteroatom is not attached to the N of the ring of imidazopyridyl), said heteroatoms being selected from the group consisting of O, S and N (optionall
