YUANQING TANG,MATTHEW SCHEIDEMAN,ZOLTAN F. KANYO,SHILI CHEN,ASHOKE BHATTACHARJEE,ERIN M. DUFFY
申请号：
ARP120101303
公开号：
AR088781A1
申请日:
2012.04.16
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Claim 1: A compound characterized in that it has the formula (1) or a tautomer thereof, or a pharmaceutically acceptable salt, ester or prodrug of said compound or tautomer, where X¹ is CR¹ or N； X² is CR² or N； X³ is CR³ or N； X⁴ is CR⁴ or N； X⁵ is CR⁵ or N； with the proviso that X¹,X2,X3,X830808,And x830909 incomplete n； y8310 is cr8310o n； y831181；es CR o 6N Y es CR o N Y es CR o N Y es CR o N con la condici n de que YY8311,Y831222,Y8313,Not all N at R1,R2,R830808,R83099,R8310,R8311th,R831222 and r83044 were selected from (a) hydrogen, (b) f, (c) Cl, (d) Br, (E) I, (f) - CF 8323, respectively；(G) -CF H (h) -CFH(I) -OCF(J) -OCF H (k) -OCFH(L) -OCH(M) -CN (n) -N(O) -NO(P) -NR R(Q) -NR C (O) R(R) -C (O) NR R(S) -OR(t) -COH, (u) -CO (C₁₋₈-alkyl),(V) -COR(W) -NR (CNR) NR R(X) -S (O) R(Y) -NR S (O) PR(Z) -SR(Aa) -SCF(Bb) -C (CF) H-NH-CHR R(CC) - coordination 1,(Dd) - (OCH CH) R(Ee) - (OCH CH) OR(ff) -alkyl C₁₋₈,(Gg) -alquenilo C(hh) -alkynyl C₂₋₈,(ii) - (C₁₋₈-alkyl) - (3-14 membered saturated, unsaturated or aromatic heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur),(jj) - (C₁₋₈-alkyl) - (3-14 membered saturated, unsaturated or aromatic carbocycle),(KK) - halide (LL) - saturated, unsaturated or aromatic heterocycle of 3-14 members, including one or more heteroatoms selected from the nitrogen, oxygen and sulfur groups (mm)； saturated, unsaturated or aromatic carbon of 3-14 members； and (NN) - chr1-nh - (saturated heterocycle), The unsaturated or aromatic of 3-14 members, including one or more heteroatoms selected from the nitrogen, oxygen, and sulfur groups；Each (FF) to (NN) can be replaced by one or more R2；On the other hand, two alternatives were selected from r8310,R8311th,R831222 and r831222 shall be combined with carbon atoms to form (a) 3-7 members saturated or unsaturated carbides or unsaturated carbides, or (b) 3-7 members saturated or unsaturated heterocycles containing one or more heteroatoms sele
