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Compounds that are modulators of S1P modulating agents and \/ or ATX
专利权人:
BIOGEN IDEC MA INC.
发明人:
申请号:
ARP130102687
公开号:
AR091929A1
申请日:
2013.07.29
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
The compounds of the present are used as bronchodilators, anti Asthmatic, antiinflammatory and antirheumatic.Claim 1: a compound represented by the formula (1) or a pharmaceutically acceptable Salt of this, where X is o, S (or \u02b3, nr\u00b9\u00b2), C (o) or ch\u2082, where r is 0, 1 or 2 a\u00b9,A-squared and a\u2077 are each independently cr\u00b2 or N and A\u00b3, a\u2075 a\u2076 are each independently cr\u00b2, C (n \u2082 R\u00b2), or nr\u00b9\u2079, where at least three of a\u00b9, a-squared, A\u00b3, a\u2075,A\u2076 and a\u2077 are cr\u00b2 (R\u00b2 \u2082 or (c) - - - - - indicates a simple or Double Bond r\u00b9 is a c\u2086\u208b\u2082\u2080 alkyl, a carbociclilo c\u2083\u208b\u2081\u2084, a heterociclilo 3 to 15 members,A c\u2086\u208b\u2081\u2080 aryl or heteroaryl 5 or 14 members, where r\u00b9 can be replaced optionally with one to six r\u2076 selected independently for each occurrence, R\u00b2,Selected irrespective of the group consisting of hydrogen, Halo, cyano, Nitro, hydroxyl, c\u2081\u208b\u2086 carboxy alkyl, cycloalkyl, haloalquilo c\u2081\u208b\u2086, c\u2083\u208b\u2088, halocicloalquilo c\u2083\u208b\u2088 c\u2081\u208b\u2086, alkoxy,Haloalcoxi c\u2081\u208b\u2086, cicloalcoxi c\u2083\u208b\u2088, halocicloalcoxi c\u2083\u208b\u2088, alcanoilo c\u2081\u208b\u2086 (alkyl, amino, c\u2081\u208b\u2086) amino - n, N, N - (alkyl amino c\u2081\u208b\u2086), alcoxicarbonilo c\u2081\u208b\u2086, alcanoiloxi c\u2081\u208b\u2086, carbamoilo,N - (alkyl carbamoilo c\u2081\u208b\u2086), N, N - (alkyl c\u2081\u208b\u2086) carbamoilo, alquilamido c\u2081\u208b\u2086, mercapto, Alquiltio c\u2081\u208b\u2086, alquilsulfonilo c\u2081\u208b\u2086, sulfamoilo, N - (alkyl c\u2081\u208b\u2086) sulfamoilo, N,N - (alkyl c\u2081\u208b\u2086) sulfamoilo and alquilsulfonamido c\u2081\u208b\u2086 r\u00b3 each and every r\u2074 is independently Hydrogen, an alkyl c\u2081\u208b\u2086, carboxy,Or a alquenilo c\u2082\u208b\u2086 or r\u00b3 and r\u2074 along with the carbo
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