A compound having the formula: ** Formula ** or a tautomer thereof, or a pharmaceutically acceptable salt or ester of said compound or tautomer, wherein X1 is CR1 or N； X2 is CR2 or N； X4 is CR4 or N； X5 is CR5 or N； R1, R2, R4, and R5 are each independently selected from (a) hydrogen, (b) F, (c) Cl, (d) Br, (e) I, (f) -CF3, (g) -CF2H , (h) -CFH2, (i) -OCF3, (j) -OCF2H, (k) -OCFH2, (l) -OCH3, (m) -CN, (n) -N3, (o) -NO2, ( p) -NR11R11, (q) - NR11C (O) R11, (r) -C (O) NR11R11, (s) -OR11, (t) -COH, (u) -CO (C1-C8 alkyl), ( v) -COR11, (w) -NR11 (CNR11) NR11R11, (x) -S (O) pR11, (y) -NR11S (O) pR11, (z) -SR11, (aa) -SCF3, (bb) -C (CF3) H-NH-CHR11R11, (cc) -COOR11, (dd) - (OCH2CH2) tR11, (ee) - (OCH2CH2) tOR11, (ff) -C1-C8 alkyl, (gg) -C2 alkenyl -C8, (hh) -C2-C8 alkynyl, (ii) - (C1-C8 alkyl) - (3-14 membered saturated, unsaturated or aromatic heterocycle containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur), (jj) - (C1-C8 alkyl) - (saturated, unsaturated or aromatic carbocycle of 3-14 members), (kk) -haloalkyl, (ll) saturated, unsaturated or aromatic 3-14 member heterocycle which contains one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, (mm) saturated, unsaturated or aromatic carbocycle of 3-14 members, and (nn) -CHR11-NH- (saturated, unsaturated or aromatic heterocycle of 3-14 members containing one or more heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur)； wherein each (ff) to (nn) is optionally substituted with one or more R12； in which: ** Formula **Un compuesto que tiene la fórmula: **Fórmula** o un tautómero del mismo, o una sal farmacéuticamente aceptable o éster de dicho compuesto o tautómero, en la que X1 es CR1 o N； X2 es CR2 o N； X4 es CR4 o N； X5 es CR5 o N； R1, R2, R4, y R5 se seleccionan cada uno independientemente entre (a) hidrógeno, (b) F, (c) Cl, (d) Br, (e) I, (f) -CF3, (g) -CF2H, (h) -CFH2, (i) -OCF3, (j) -OCF2H, (k) -OCFH2, (l) -OCH3
