This provides compounds useful as inhibitors of Protein Kinases, pharmaceutically acceptable compositions of these Compounds, and Methods of using such compounds.Compounds useful to treat various conditions.Claim 1: a compound of formula (1) or a pharmaceutically acceptable Salt of the compound, which is nr u2074: x u00b9 -, N -, o - cr u2074 cr u2074r u2074； X is - nr u2075, N,- cr u2075r u2075 or - cr u2075； X is n or cr u2076； x u2074 is n or cr u2077； x u2075 is n or CH, C； where at least one of x u00b9, X, X, x u2074 or x u2075 is n； G H, or,Or or N (R) (R)； The Ring a is an optionally substituted phenyl Group selected, a ring carboc u00edclico 3 - 8 members partially saturated or unsaturated.A monocyclic heteroaryl Ring of 5 - 6 members that have 1-4 heteroatoms selected irrespective of Nitrogen, Oxygen or Sulfur.A Heterocyclic Ring of 4 - 7 Member partially unsaturated or saturated with 1 - 4 heteroatoms selected irrespective of Nitrogen, Oxygen or Sulfur.Or a 7 - 10 Member Ring bicyclic aryl or partially saturated, unsaturated Ring； each R is independently Hydrogen or optionally substituted aliphatic Group Selected c u2081 u208b u2086,PHENYL ring, a carboc u00edclico 3 - 8 members partially saturated or unsaturated.A Heterocyclic Ring of 4 - 7 members that have 1-4 heteroatoms selected irrespective of Nitrogen, Oxygen or Sulfur.Monocyclic heteroaryl Ring or a 5 - 6 members that have 1-4 regardless of nitrogen heteroatoms selected,Oxygen or Sulphur or Two R groups； in the same nitrogen taken together with the nitrogen Atom to which they are United to form a Heterocyclic Ring of 4 - 7 members have 0-2 heteroatomsSelected additional regardless of Nitrogen, Oxygen or Sulfur.Or a heteroaryl Ring of 4 - 7 members have 0 - 4 additional heteroatoms selected irrespective of nitrogenOxygen or Sulfur； r u00b9 is a Group r u00b9 Warhead, which is joined to an adjacent Atom to Atom where t is attached； each is independently R u00b2 Halogen haloalquilo, - R, -, -, -, - CN
