JENNIFER R. ALLEN,SHANNON RUMFELT,KRISTIN L. ANDREWS,JAMES BROWN,CHESTER CHENGUANG YUAN,ROBERT M. RZASA,JIAN J. CHEN,NING CHEN,ESSA HU HARRINGTON,QINGYIAN LIU,ALBERT AMEGADZIE,THOMAS T. NGUYEN,ALEXAND
申请号：
ARP130100649
公开号：
AR090203A1
申请日:
2013.02.28
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Compounds containing these substances and their preparation process. At present, it also provides methods for the treatment of diseases that can be inhibited by PDE10, such as obesity, non insulin diabetes, schizophrenia, bipolar disorder, obsessive-compulsive disorder, Huntington's disease, etc. Property 1: a compound characterized by a formula (1) or a pharmaceutically acceptable salt, tautometer, or stereoisomer, wherein: each P and Q is independent of 0, 1, 2, 3, 4, 5 or 6； the sum of P and Q is 1, 2, 3, 4, 5 or 6； m is 0, 1, 2, 3 or 4；A is a compound ring (2) composed of 9 to 10 members,a. W-t-d lt group, selected from the following groups: - n = cr8309a-n lt；；NR -N 3DC 26lt-No. 8311 - (C = O) - N lt；NR -CR R - (C 3DO) -N 26lt-No. 8311 - (so8322) - N lt；-CR 3DCR -N 26lt-CR⁸=N-N<；；-CR R - (C 3DO) -N 26lt-CR R -NR - (C 3DO) -N 26lt-CR R -O- (C 3DO) -N 26lt-CR R - (SO) -N 26lt-O- (C 3DO) -N 26lty -O-CR R - (C 3DO) -N 26ltJ is independently N or CR³ᶜ；E. X, y, Z are independent n or cr83088；where 0, 1, 2 or 3 of E, X, Y, and Z are N； (a) when J is N, then G is R¹ or (C = O) R¹；where R¹ binds through carbon； (b) when J is CR³ᶜ；Then G is R1,- No. first；-NH (C 3DO) R-Or1,- (C 3DO) RO-chr R 2；R 1 is connected by carbon or nitrogen； the ring containing P and Q contains 0, 1 or 2 N atoms and 0, 1 or 2 N or S atoms； R 1 is a single ring of 5 or 6 members saturated, partially saturated or unsaturated or unsaturated, or a double ring of 9 or 10 members saturated, partially saturated or unsaturated or unsaturated O is made of nitrogen, each of which contains 0, 1, 2, 3 o r 4 N atoms and 0, 1 or 2 O or S atoms； each R 1 is replaced by 0, 1, 2 or 3 r8313 groups independently；R2 is an independent h, oh, Alq c832131；a saturated, partially saturated or unsaturated monocyclic ring of 5 or 6 members bonded by carbon or bonded by nitrogen, where each of said rings contains 0, 1, 2, 3 or 4 atoms of N and 0, 1 or 2 atoms of O or S； where each R² alq C₁₋₄ or monocyclic ring is in
