The pharmaceutical ingredients containing these substances regulate the activities of Janus quinassa (JAK) and help to treat diseases related to Jacques activities, including inflammation, autoimmune disorders, cancer and other diseases. 1. Characteristic requirement 1: a formula compound (1) or a salt acceptable for drug use, wherein: X is CR1 or N； and is Cr * or N； W is Cr * or N； Z is Cr * 8308o or N； V is cr83090 or N； wherein the aromatic ring of six members consisting of carbon atoms x, y, W, Z and V has 0, 1 or 2 nitrogen rings； R1,R2,R3,R830808,R83099, each is independent of H, halo, CN, no 8322；1. Lease land No. c833218331 and 832626；C₂₋₆ alkenyl,1. C 83228331 asphalt；C₁₋₆ haloalkyl,Cy, -Cquile-Cy alkylene, ORᵃ,No. 7497； r75844,74955,S (3DO) RS (3DO) NR RC (3DO) RC (3DO) ORC (3DO) NR ROC (3DO) ROC (3DO) NR RNo. 7580； (= O) r74969；No. 7580； (= O) or7496；NR S (3DO) RNR S (3DO) NR RAnd Cr 75060； r7510； or 749191,y CR R NR Rwherein said C₁₋₆ alkyl is optionally substituted by 1, 2, or 3 independently selected Rˣ groups； R⁶ is F, methyl, -OH, or -OCH₃；Each CY is independently selected, independent of 3-6 single cycle bicycles, 4-6 members of single cycle heterosexuality, phenyl and 5-6 members of single cycle heterosexuality, and is replaced by 1, 2 or 3 r750101, respectively；R758080,R74966,R74977,and Rᶠ is independently selected from H, C₁₋₆ alkyl,C₁₋₆ haloalkyl,Cy1,and -C₁₋₃-Cy¹ alkylene；wherein said C₁₋₆ alkyl is optionally substituted with 1, 2, or 3 independently selected Rʰ groups； or every Rᵉ and Rᶠ,together with the nitrogen atom to which they are attached, they form a 4-6 membered monocyclic heterocycloalkyl ring； which is optionally substituted with 1, 2, or 3 independently selected Rᵍ groups； each Rᵇ is independently selected from C₁₋₆ alkyl,C₁₋₆ haloalkyl,Cy1,and -C₁₋₃-Cy¹ alkylene；wherein said C₁₋₆ alkyl is optionally substituted with 1, 2, or 3 independently selected Rʰ groups； Rᵒ and Rᵖ,taken together with the carbon atom to which they are attach
