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PEPTIDES AYANT UNE ACTIVITÉ PHARMACOLOGIQUE POUR LE TRAITEMENT DE TROUBLES ASSOCIÉS À LA MIGRATION DE CELLULES ALTÉRÉES, TELS QUE LE CANCER
专利权人:
PHARMAPHELIX S.R.L
发明人:
申请号:
EP07786192.0
公开号:
EP2049562B1
申请日:
2007.07.19
申请国别(地区):
EP
年份:
2013
代理人:
摘要:
Peptides and their functionally equivalent derivatives, in salified or non-salified form, with the general formula L 1 -X 1 -X 2 -X 3 -X 4 , wherein: L 1 is H, or acyl, or any natural or non-natural amino acid, optionally N-acylated, N-alkylated and/or C±-alkylated; X 1 and X 3 , which are equal or different, are any natural or non-natural basic amino acid, optionally N-alkylated and/or C±-alkylated; X 2 is any natural or non-natural amino acid, optionally N-alkylated and/or C±-alkylated, with the proviso that it is not glycine and amino acids mono-substituted on the ± carbon atom with a linear or cyclic alkyl group, from 1 to 10 carbon atoms, and amino acids mono-substituted on the ± carbon atom with a linear or cyclic alkyl group containing 4 to 10 carbon atoms, or amino acids mono-substituted on the ± carbon atom with an alkyl group containing 1 to 8 carbon atoms, optionally substituted with a carbamoyl, hydroxyl or aromatic group; X 4 is any natural or non-natural hydrophobic amino acid, optionally C±-alkylated and/or amidated at the C-terminal end, or any hydrophobic amino alcohol, or a hydrophobic gem-diamine, optionally N'-alkylated or N'-acylated.
来源网站:
中国工程科技知识中心
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