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用於治療與異常細胞遷移相關的諸如癌症等疾病的具有藥學活性的肽
专利权人:
PHARMAPHELIX S.R.L.
发明人:
CARRIERO, MARIA VINCENZA,DE ROSA, MARIO,PAVONE, VINCENZO
申请号:
HK10100460.9
公开号:
HK1136304B
申请日:
2010.01.15
申请国别(地区):
HK
年份:
2013
代理人:
摘要:
Peptides and their functionally equivalent derivatives, in salified or non-salified form, with the general formula L 1 -X 1 -X 2 -X 3 -X 4 , wherein: L 1 is H, or acyl, or any natural or non-natural amino acid, optionally N-acylated, N-alkylated and/or C±-alkylated; X 1 and X 3 , which are equal or different, are any natural or non-natural basic amino acid, optionally N-alkylated and/or C±-alkylated; X 2 is any natural or non-natural amino acid, optionally N-alkylated and/or C±-alkylated, with the proviso that it is not glycine and amino acids mono-substituted on the ± carbon atom with a linear or cyclic alkyl group, from 1 to 10 carbon atoms, and amino acids mono-substituted on the ± carbon atom with a linear or cyclic alkyl group containing 4 to 10 carbon atoms, or amino acids mono-substituted on the ± carbon atom with an alkyl group containing 1 to 8 carbon atoms, optionally substituted with a carbamoyl, hydroxyl or aromatic group; X 4 is any natural or non-natural hydrophobic amino acid, optionally C±-alkylated and/or amidated at the C-terminal end, or any hydrophobic amino alcohol, or a hydrophobic gem-diamine, optionally N'-alkylated or N'-acylated.
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中国工程科技知识中心
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