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ACC inhibitors and Uses Thereof
专利权人:
GILEAD APOLLO; LLC
发明人:
GERALDINE C. HARRIMAN,SHOMIR GHOSH
申请号:
ARP160103255
公开号:
AR106472A1
申请日:
2016.10.25
申请国别(地区):
AR
年份:
2018
代理人:
摘要:
The present application provides useful compounds as inhibitors of acetyl CoA carboxilasa (ACC).Their composition and usage. Page: 1 1. Claim 1: a compound of formula (1) or (2),Or a pharmaceutically acceptable salt, stereoisomer or mixture thereof, wherein X- yes.o -N (R) -Each Q1 and Q2 is independent or s; R1 is hydrogen, halogen, CN, no832222;-R8310,-R O-SR, R 2 is hydrogen halide, R8310,-OR -SR -N (R)-N (R) C (O) R -C (O) N (R)-N (R) C (O) N (R)-N (R) C (O) OR, -OC (O) N (R) ₂. -N (R) S (O) ₂R, -S (O) ₂N (R) ₂,-C (O) R, -C (O) OR, -OC (O) R, -S (O) R, -S (O) ₂R, or Hy; or R¹ and R² can optionally be taken together to form an optionally substituted or unsaturated saturated 3-8 membered carbocyclic monocyclic, or a heterocycle-,Ben ShuO a 5-6 member non orthogonal ring; HY is an alternative ring selected from a saturated or partially unsaturated 3-8 member non orthogonal single ring, including 1-4 non normal atoms, selected from nitrogen, oxygen and sulfur; A single ring consisting of 5-6 members, consisting of 1-4 heteroatoms, independently selected from nitrogen, oxygen and sulfur; a saturated or partially unsaturated double ring consisting of 6-10 members, consisting of 1-5 heteroorganisms, selected from nitrogen, oxygen and sulfur.and a 7-10 membered heteroaryl bicyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen and sulfur; each R is independently selected from hydrogen, deuterium, and an optionally substituted group selected from aliphatic C₁₋₆; a saturated or partially unsaturated 3-8 membered monocyclic carbocyclic ring; phenyl; an 8-10 membered bicyclic aryl ring; a saturated or partially unsaturated 3-8 membered monocyclic heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur;a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen and sulfur; a saturated or partially unsaturated 6-10 membered bicyclic heterocyclic ring having 1-5
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