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COMPOSITIONS POUR OESTROGENES CONJUGUES ET METHODES ASSOCIEES
专利权人:
WATSON LABORATORIES; INC.
发明人:
HO, THOMAS
申请号:
CA2539872
公开号:
CA2539872C
申请日:
2004.08.27
申请国别(地区):
CA
年份:
2014
代理人:
摘要:
Oral conjugated estrogen formulations are disclosed and described. In oneaspect, the oral formulation may be a tablet having a core and one or morecoatings thereon. In addition to conjugated estrogen ingredients, the core mayinclude one or more organic excipients and one or more inorganic excipients.In one aspect, the organic excipients may include less than about 20 % w/w ofa cellulose ingredient, and less than about 50 % w/w of a sugar ingredient. Inanother aspect, the inorganic excipients may include less than about 10 % w/wof a calcium phosphate tribasic ingredient. In yet another aspect, theformulation does not crack when stored at about 40 ~C and about 75 % relativehumidity for about 2 months.
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