GLUCOCORTICOID RECEPTOR AGONIST COMPRISING 2, 2, 4- TRIMETHYL-6-PHENYL-1,2-DIHYDROQUINOLINE DERIVATIVES HAVING SUBSTITUTED OXY GROUP

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专利权人:

AYUMI PHARMACEUTICAL CORPORATION

发明人:

KATO, MASATOMO,TAKAI, MIWA,MATSUYAMA, TAKAHIRO,KUROSE, TATSUJI,HAGIWARA, YUMI,MATSUDA, MAMORU,MORI, TOSHIYUKI,IMOTO, KENJI,DOTA, ATSUYOSHI

申请号：

MYPI2010005303

公开号：

MY158747A

申请日:

2009.05.12

申请国别(地区):

MY

年份:

2016

代理人:

摘要：

THE PRESENT INVENTION IS RELATED TO GLUCOCORTICOID RECEPTOR AGONISTS COMPRISED OF A COMPOUND REPRESENTED BY FORMULA (1) WHICH IS 2,2,4-TRIMETHYL-6-PHERNYL-1,2- DIHYDROQUINOLINE DERIVATIVE OR A SALT THEREOF AND NOVEL PHARMACOLOGICAL EFFECTS OF THE GLUCOCORTICOID RECEPTOR AGORNISTS. IN THE FORMULA (1), R1 REPRESENTS FORMULA (2A), (3A), (4A) OR (5A)’； R2 REPRESENTS -(CQ)-R8, -(CO)O-R9, OR THE LIKE； R2-O- IS SUBSTITUTED AT THE 4- OR -5-POSITION OF BENZENE RING A； R3 REPRESENTS A LOWER ALKYL GROUP； R4, R5, R6 OR R7 REPRESENTS A HALOGEN ATOM, A LOWER ALKYL GROUP WHICH MAY HAVE A SUBSTITUENT, OR THE LIKE； M, N, P OR Q REPRESENTS 0,1 OR THE LIKE； R8, R9 OR THE LIKE REPRESENTS A LOWER ALKYL GROUP WHICH MAY HAVE A SUBSTITUENT, A LOWER ALKENYL GROUP, OR THE LIKE.

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