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Imidazo [1,2-a] hydroxy substituted pyridine-3-carboxamides and their use as stimulators of soluble guanylate cyclase
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
VAKALOPOULOS, Alexandros,HARTUNG, Ingo,FOLLMANN, Markus,JAUTELAT, Rolf,STRAUB, Alexander,HAßFELD, Jorma,LINDNER, Niels,SCHNEIDER, Dirk,WUNDER, Frank,STASCH, Johannes-Peter,REDLICH, Gorden,LI, Volkhart
申请号:
ES13789237
公开号:
ES2640616T3
申请日:
2013.11.04
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Compound of formula (I) ** Formula ** in which A represents CH2, CD2 or CH (CH3), R1 represents (C4-C6) alkyl, cycloalkyl (C3-C7), pyridyl or phenyl, which may be substituted alkyl ( C4-C6) up to six times with fluorine, cycloalkyl (C3-C7) may be substituted with one to 4 substituents independently selected from each other from the group of fluorine, trifluoromethyl and (C1-C4) alkyl, and pyridyl may be substituted with 1 to 3 substituents independently selected from each other from the group of fluorine, trifluoromethyl and (C1-C4) alkyl, and phenyl may be substituted with 1 to 4 substituents independently selected from the group of halogen, cyano, monofluoromethyl, difluoromethyl, trifluoromethyl, (C1-alkyl) -C4), cycloalkyl (C3-C6), alkoxy (C1-C4), difluoromethoxy and trifluoromethoxy or may be substituted in 2 adjacent carbon atoms of the phenyl with a difluoromethylenedioxy bridge, R2 represents hydrogen, (C1-C4) alkyl, cyclopropyl mo nofluoromethyl, difluoromethyl or trifluoromethyl, R3 represents a group of formula ** Formula ** in which * represents the point of attachment to the carbonyl group, L1A represents a bond or alkanediyl (C1-C4), in which alkanediyl (C1-C4 ) may be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, (C1-C4) alkyl, cycloalkyl (C3-C7), hydroxy and (C1-C4) alkoxy, L1B represents a bond or alkanediyl ( C1-C4), L1C represents a bond or alkanediyl (C1-C4), in which alkanediyl (C1-C4) may be substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, (C1-C4) alkyl ), (C3-C7) cycloalkyl, hydroxy and (C1-C4) alkoxy, R7 represents (C1-C6) alkyl or (C2-C6) alkynyl, in which (C1-C6) alkyl is substituted with 1 to 3 substituents independently selected from the group of fluorine, trifluoromethyl, difluoromethoxy, trifluoromethoxy and benzyloxy, in which benzyloxy is substituted with 1 to 3 halogen substituents, and in which in addition (C1-C6) alkyl
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