A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt, a polymorph or a solvate thereof, wherein: X is independently selected from: a bond , O, S, NH, N (C1-4 alkyl), CH2, CH2CH2, CH (C1-4 alkyl), OCH2, CH2O, OCH2CH2 and CH2CH2O； Ring A is independently ** Formula ** Ring B is independently a 4- to 7-membered saturated heterocycle containing carbon atoms, the nitrogen atom shown in Ring B and an additional 0-1 heteroatom selected from N, O and S； and ring B is substituted with 0-4 R2； R1 is independently ** Formula ** phenyl, benzyl, naphthyl or a 5-10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O and S； wherein said phenyl, benzyl, naphthyl and heteroaryl are each substituted with 0-3 R6； R2, in each case, is independently selected from:>； = O, OH, halogen, C1-6 alkyl substituted with 0-1 R12, C1-6 alkoxy substituted with 0-1 R12, C1-4 haloalkyl substituted with 0-1 R12, C1-4 haloalkoxy substituted with 0-1 R12, - (CH2) m-C3-6 carbocycle substituted with 0-1 R12 and - (CH2) m- (5 to 10 membered heteroaryl containing carbon atoms and 1 -4 heteroatoms selected from N, NR11, O and S)； wherein said heteroaryl is substituted with 0-1 R12； when two R2 groups are attached to two different carbon atoms, they can be combined to form a bridge of 1 to 3 member carbon atoms over the B ring； when two R2 groups are attached to the same carbon, they can be combined, together with the carbon atom to which they are attached, to form a 3 to 6 member carbon atom containing a spiro ring； R3 is independently selected from: C1-6 alkyl substituted with R10, C2-6 alkenyl substituted with R10, C2-6 alkynyl substituted with R10, C1-4 haloalkyl substituted with R10, -O (CH2) 1-2O (CH2) 1 -4R10, OR9, SR9, C (O) OR9, CO2R9, S (O) R9, SO2R9 and CONHR9； R4 and R4a are independently selected from: H, halogen, C1-6 alkyl, C1-6 alkoxy and - (CH2) m-C3-6 carbocycle； R5, in each case, is independently se
