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GPR40 pyrrolidine modulators for the treatment of diseases such as diabetes
专利权人:
Bristol-Myers Squibb Company
发明人:
SUN, Chongqing
申请号:
ES15723096
公开号:
ES2671402T3
申请日:
2015.05.06
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula (I): ** Formula ** or a stereoisomer, a tautomer, a pharmaceutically acceptable salt or a solvate thereof, in which: X is independently selected from: a bond, O, S, NH, N (C1-4 alkyl), CH2, CH2CH2, CH (C1-4 alkyl), OCH2, CH2O, 10 OCH2CH2 and CH2CH2O; Ring B is independently a 4- to 7-membered saturated heterocycle containing carbon atoms, the nitrogen atom shown in Ring B and an additional 0-1 heteroatom selected from N, O and S; and ring B is substituted with 0-4 R2; R1 is independently phenyl, benzyl, naphthyl or a 5-10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O and S; wherein said phenyl, benzyl, naphthyl and heteroaryl are each substituted with 0-3 R6; R2, in each case, is independently selected from:>; = O, OH, halogen, C1-6 alkyl substituted with 0-1 R12, C1-6 alkoxy substituted with 0-1 R12, C1-4 haloalkyl substituted with 0-1 R12, C1-4 haloalkoxy substituted with 0-1 R12, carbocycle - (CH2) m-C3-6 substituted with 0-1 R12, and - (CH2) m- (5-10 membered heteroaryl containing carbon atoms and 1-4 heteroatoms selected from N, NR11, O, and S); wherein said heteroaryl is substituted with 0-1 R12; when two R2 groups are attached to two different carbon atoms, they can be combined to form a 1 to 3 member carbon atom bridge over the B ring; when two R2 groups are attached to the same carbon atom they can be combined, together with the carbon atom to which they are attached, to form a 3 to 6 member spiro ring containing carbon atoms; R3 is independently selected from: H, halogen, CN, OH, CO2H, C1-6 alkyl substituted with 0-1 R10, C2-6 alkenyl substituted with 0-1 R10, C2-6 alkynyl substituted with 0-1 R10, haloalkyl C1-4 substituted with 0-1 R10, haloalkoxy C1-6 substituted with 0-1 R10, O (CH2) 1-2O (CH2) 1-4 R10, OR9, SR9, C (O) OR9, CO2R9, S ( O) R9, SO2R9, CONHR9, - (O) n- (CH2) m- (phenyl substituted with 0-2 R10) and - (O) n- (CH2) m- (5 to 10-membered heteroaryl containing atoms carbon and 1
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